Acidum Alendronicum [Inn-Latin]

Acidum Alendronicum [Inn-Latin] Brand names, Acidum Alendronicum [Inn-Latin] Analogs

Acidum Alendronicum [Inn-Latin] Brand Names Mixture

No information avaliable

Acidum Alendronicum [Inn-Latin] Chemical_Formula

C₄H₁₃NO₇P₂

Acidum Alendronicum [Inn-Latin] RX_link

http://www.rxlist.com/cgi/generic/alendron.htm

Acidum Alendronicum [Inn-Latin] fda sheet

Acidum_Alendronicum_[Inn-Latin] FDA

Acidum Alendronicum [Inn-Latin] msds (material safety sheet)

Acidum_Alendronicum_[Inn-Latin] MSDS

Acidum Alendronicum [Inn-Latin] Synthesis Reference

M. I. Kabachnik et al., Bull. Acad. Sci. USSR,.27, 374 (1978)

Acidum Alendronicum [Inn-Latin] Molecular Weight

249.096 g/mol

Acidum Alendronicum [Inn-Latin] Melting Point

233 - 235 ^oC

Acidum Alendronicum [Inn-Latin] H₂O Solubility

1mg/L

Acidum Alendronicum [Inn-Latin] State

Solid

Acidum Alendronicum [Inn-Latin] LogP

-3.198

Acidum Alendronicum [Inn-Latin] Dosage Forms

Tablets (6.53, 13.05, 45.68, 52.21 or 91.37 mg of alendronate monosodium salt trihydrate)

Acidum Alendronicum [Inn-Latin] Indication

For the treatment and prevention of osteoporosis in women and Paget's disease of bone in both men and women.

Acidum Alendronicum [Inn-Latin] Pharmacology

Alendronate, a second-generation bisphosphonate is the first member of a group of drugs which strengthens bone. Alendronate is used to reduce hypercalcemia in tumor-induced bone disease, to treat corticosteroid-induced osteoporosis and Paget's disease, and to prevent osteoporosis in postmenopausal women.

Acidum Alendronicum [Inn-Latin] Absorption

Relative to an intravenous (IV) reference dose, the mean oral bioavailability of alendronate in women was 0.7% for doses ranging from 5 to 40 mg when administered after an overnight fast and two hours before a standardized breakfast. Oral bioavailability of the 10 mg tablet in men (0.59%) was similar to that in women (0.78%) when administered after an overnight fast and 2 hours before breakfast.

Acidum Alendronicum [Inn-Latin] side effects and Toxicity

Alendronate can damage the esophagus both by toxicity from the medication itself and by nonspecific irritation secondary to contact between the pill and the esophageal mucosa, similar to other cases of "pill esophagitis."

Acidum Alendronicum [Inn-Latin] Patient Information

Acidum Alendronicum [Inn-Latin] Organisms Affected

Humans and other mammals